What is pharmaceutical compounding — and why is it at the centre of the GLP-1 controversy?
Compounding is a century-old pharmacy practice that became a multi-billion dollar flashpoint when GLP-1 medications went into shortage. Here is what it actually is, what the controversy is really about, and what it means for patients.
The SA access problem: who gets GLP-1s and who does not
Private prescription, medical aid, out-of-pocket cash, and the growing grey market. What getting onto GLP-1 treatment actually looks like in South Africa right now.
Why the GLP-1 shortage keeps happening — and when it might resolve
Global demand has outpaced manufacturing capacity since 2022. Understanding why — and what manufacturers are doing about it — matters for every patient planning their treatment.
Compounded GLP-1s in South Africa — the grey market and its real risks
Some South Africans are sourcing compounded or “research grade” semaglutide online. Here is an honest assessment of what that means legally, medically and practically.
Ask the expert: “Can I drink on semaglutide?”
The answer and the nuance behind it — from what the interaction actually involves, to the surprising finding that GLP-1s may reduce your desire to drink anyway.
Ask the expert: “I missed two injections — what do I do?”
Practical guidance, not a disclaimer. What actually happens to the medication in your system, and the specific steps to take depending on when you missed and why.
Ask the expert: “Why did I stop losing weight at month 3?”
The plateau explained properly — including the part about metabolic adaptation that most prescribers do not take time to explain.
Ask the expert: “Is it safe to use GLP-1s while trying to conceive?”
The evidence gap, honestly described. What the current data shows about GLP-1 exposure in early pregnancy — and the specific guidance that applies before conception.
Ask the expert: “My medical aid won’t cover this. What are my options in South Africa?”
Practical pathways, honest tradeoffs and the questions worth asking your scheme — from a South African perspective.